The American Association of Physicists in Medicine (AAPM) Subcommittee on Low Energy Interstitial Brachytherapy Dosimetry has determined that the Advantage I-125 seed complies with the AAPM's dosimetric prerequisites as set forth in "Dosimetric Prerequisites for Routine Clinical Use of New Low Energy Photon Interstitial Brachytherapy Sources: Recommendations of the American Association of Physicists in Medicine Radiation Therapy Committee," Med. Phys., 25, 2269-2270 (1998). A copy of the AAPM prerequisites can be obtained from MD Anderson Cancer Center website.
The vendor provides air-kerma strength calibrations that are indirectly traceable to the air-kerma strength standard (SK,N99) for low energy photon emitting seeds maintained by NIST using its wide angle free-air chamber (WAFAC)
A full set of TG-43 dosimetric parameters is available, supporting both calculation of the 2D dose-rate distribution and the 1-D isotropic point source approximation. This set of dosimetric parameters must be performed by independent investigators, and have been accepted for publication by a peer-reviewed journal.
The vendor has assured that the calibration from NIST has been transferred to the ADCLs.
The vendor has implemented a program of periodically intercomparing its air-kerma strength calibrations with NIST primary standard and the secondary standards "maintained by the ADCL's"
For more information on brachytherapy seeds that have met the requirements, visit the AAPM/RPC Registry website.
